After shoplifting some bread one chilly March night, just before the start of a new academic year at Kansei University in western Tokyo, former high school track and field star Kakeru Kurahara runs through the city streets. Though he has grown disillusioned with the sport, he feels as if he could keep running forever . . . but to where, and for what? His reverie is broken by a mysterious boy on a bike who has been following him, a fellow student at Kansei University named Haiji Kiyose, who also happens to be a runner.

Impressed by Kakeru’s agility, Haiji Kiyose persuades Kakeru to move into Chikusei-so, a run-down dormitory where he lives with eight other boys, including identical twins Jota and Joji, honor student Shindo, detail-oriented Yuki, trivia junkie King, Tanzanian international student Musa, nicotine-loving Nico, and manga otaku Prince. None of the students know that Chikusei-so is the historic home of the Kansei University Track and Field team.

At Kakeru's welcoming party, Kiyose reveals his grand plan: assembling a 10-man team of runners to compete in the Hakone Ekiden, a legendary college marathon relay race. Except for Kakeru and Kiyose, the Chikusei-so gang aren't athletic—or interested in competing. But Kiyose’s enthusiasm wins them over and they agree to this crazy plan.

Over the course of ten months, this ragtag team will put aside their differences to pursue an elusive dream . . . and gain so much more than they ever expected.