Greg Iles was born in Germany in 1960, where his father ran the US Embassy Medical Clinic during the height of the Cold War. His mother was raised on a subsistence farm in Louisiana and began picking cotton at the age of three. Iles spent his youth in Natchez, Mississippi, and graduated from the University of Mississippi in 1983. While attending Ole Miss, Greg lived in the cabin where William Faulkner and his brothers listened to countless stories told by "Mammy Callie," their beloved nanny, who had been born enslaved.

Iles wrote his first novel in 1993, a thriller about Nazi war criminal Rudolf Hess, which became the first of seventeen New York Times bestsellers. Primarily set in the Deep South, his later novels have been made into films, translated into more than twenty languages, and published in more than thirty-five countries worldwide. His new novel will continue the story of Penn Cage, after the epic trilogy that ended with New York Times #1 bestseller Mississippi Blood.

Iles passed away from a 29-year battle with Mulitple Myeloma on August 15, 2025. He lived in Natchez, Mississippi with his wife Caroline and had four children.